2Klefmann R, Heckel K, Doerger M, et al. Role of PARP on iNOS pathway during endotoxin-indueedacute lung injury. Intensive Care Med, 2004, 30 1421-1431.
3Coimbra R, Melbostad H, Loomis induced acute lung injury is phosphodiesterase inhibition W, et al. LPS attenuated by effects on proinflammatory mediators, metalloproteinases, NF- kappaB, and ICAM-1 expression. J Trauma, 2006, 60:115-125.
5Seifart C, Clostermann U, Seifart U, et al. Cell- specific modulation of surfactant proteins by ambroxol treatment. Toxicol Appl Pharmaeol,2005, 203:27-35.
5Nowak D.Antmxidative features of ambroxd:usefulnes in C0PD.Pneumonol Alergol Pol,2001,69(9-10):590-593.
6Seifart C,Clostermann U,Seifart U,et al.Cell-specific modulmion of surfactant proteins by ambroxol treatment.Toxicol Appl Pharmacol,2005,203(1):27-35.
7Karima R,Matsumoto S,Higashi H,et al.The molecular pathogenesis of endotoxic shock and organ failure[J].Mol Med Today,1999,5:123-132.
8Parsons PE.Mediators and mechanisms of acute lung injury[J].Clin Chest Med,2000,21:467-476.
9Kim YK,Jang YY,Han ES,et al.Depressant effect of ambroxol on stimulated functional responses and cell death in rat alveolar macrophages exposed to silica in vitro.[J].Pharmacol Exp Ther,2002,300:629-637.
10Gibbs BF,Schmutzler W,Vollrath IB,et al.Ambroxol inhibits the release of histamine,leukotriences and cytokines from human leukocytes and mast cells[J].Inflamm Res,1999,48:86-93.
7HOLLAND M C,MACKERSIE R C,MORABITO D,et al.The development of acute lung injury is associated with worse neurologic outcome in patients with severe traumatic brain injury[J].J Trauma,2003,55(1):106-111.
8BULGER E M,NATHENS A B,RIVARA F P,et al.Management of severe head injury:institutional variations in care and effect on outcome[J].Crit Care Med,2002,30(8):1870-1876.
9ROMANINI B M,SANDRI M G,TOSI M,et al.Ambroxol for prophylaxis and treatment of bronchopulmonary complications after chest surgery[J].Int J Clin Pharmacol Res,1986,16(2):123-127.
10FEGIZ G.Prevention by ambroxol of bronchopulmonary co-mplications after upper abdominal surgery:double 2 blind Italian multicenter clinical study versus placebo[J].Lung,1991,169:69-76.