双侧后肾腺瘤报告并文献复习

Bilateral metanephric adenoma: case report and review of literature

目的:探讨后肾腺瘤(MA)的临床病例特征,提高对MA的认识。方法:观察1例MA的病理组织学表现,结合临床资料及相关文献进行分析。结果:肿瘤细胞丰富,排列密集,形态一致的单层立方上皮的小管结构。免疫组化:WT1(+),CD57散在(+),Vim散在少许(+),PCK、EMA、CK7、CD10、CD117均(-),Ki67LI:1%左右。结论:MA多为单侧,双侧少见,缺乏临床特异性及影像学诊断,术前诊断较困难,难以和恶性病变相鉴别,需术前穿刺活检或术中快速冷冻病理诊断,避免肾脏全部切除。术后需注意长期随访。

Objective：To explore the clinical characteristics of the metanephric adenoma and improve awareness of the MA. Methods：l case of Bilateral MA was reported, histopathological characteristics, clinical data and rele- vant literature of MA were also analyzed. Results：The tumor cells were rich, arrange densely, and consist of tubu- lar structure of simple cuboidal epithelium. Immunohistochemistry staining： WT1, CD57 and vim were positive, the PCK, EMA, CKT, CD10, CD117 were negative, Ki67 LI： 1%. Conclusions.. MA mostly is unilateral, bilateral rare. It has neither typical clinical nor radiological features, preoperative diagnosis and differentiated from malig- nant lesions are difficult. It required preoperative puncture biopsy or intraoperative pathological diagnosis. Partial nephrectomy is safe and feasible for these patients, however, long-time close follow-up is necessary.