主动脉弹力纤维的修复策略

STRATEGIES ON REPAIRING ELASTIC FIBERS IN AORTA

目的对主动脉弹力纤维修复的研究策略进行综述。方法查阅国内外关于弹力纤维及其修复的文献,围绕促进各组成蛋白合成、改善组装条件和减少危险因子破坏3方面进行综述。结果促进蛋白合成方面,以弹力蛋白的促表达研究较多,方法分别有基因转染、外源性因子刺激及诱导平滑肌表型转变;fibulin与赖氨酰氧化酶类有助于弹力纤维的组装,但其机制尚不明确;减少危险因子的破坏主要围绕抑制基质金属蛋白酶类的表达及其作用效应展开。结论主动脉弹力纤维的高质量修复,需保证其各组成蛋白的充足合成、有效组装并减少危险因子的破坏。

Objective To review the strategies on repairing elastic fibers in aorta. Methods Literature concerning elastic fiber as well as its repairment was consulted and summarized from three aspects： enhancement of the expressions of its components, improvement of the condition of its assembly, and reduction of the destructive effects. Results Elastin is concerned as the main protein to be enhanced with three different methods including gene transfection, stimulation with ectogenesis factors, and induction of phenotype transition of smooth muscle cell. Fibulin and lysyl oxidases show the ability to improve the assembly of the elastic fiber, while the related mechanisms are not clear. Matrix metalloproteinases are regarded as the main destructive factors, and researches focus on reducing their expression as well as their destructive effects. Conclusion To assure a high-quality repair of elastic fibers in aorta, their components should be sufficiently expressed and effectively assemblyed, and the destructive effects caused by dangerous factors should also be reduced.