哺乳动物雷帕霉素靶蛋白参与神经系统损伤修复的研究进展及其延伸意义

PROGRESS AND EXTENSIVE MEANING OF MAMMALIAN TARGET OF RAPAMYCIN INVOLVED IN RESTORATION OF NERVOUS SYSTEM INJURY

目的综述哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)参与神经系统损伤修复的可能机制。方法广泛查阅mTOR与神经系统损伤后神经修复的相关文献并进行综合分析。结果 mTOR可整合细胞外应激信号,进而调节多种细胞生物过程,参与神经系统损伤修复。结论不同途径调节mTOR信号通路活性,进而减轻神经系统损伤尤其是应激性脑损伤。mTOR可作为促进应激性脑损伤修复的新靶点。

Objective To review the possible mechanisms of the mammalian target of rapamycin （mTOR） in the neuronal restoration process after nervous system injury. Methods The related literature on mTOR in the restoration of nervous system injury was extensively reviewed and comprehensively analyzed. Results roTOR can integrate signals from extracellular stress and then plays a critical role in the regulation of various cell biological processes, thus contributes to the restoration of nervous system injury. Conclusion Regulating the activity of mTOR signaling pathway in different aspects can contribute to the restoration of nervous system injury via different mechanisms, especially in the stress-induced brain injury. mTOR may be a potential target for neuronal restoration mechanism after nervous system injury.