早发冠心病心肌梗死型与非心肌梗死型危险因素差异分析

Study on the different risk factors between myocardial infarction and non myocardial infarction in premature coronary heart disease

目的探讨早发冠心病中心肌梗死型与非心肌梗死型的危险因素差异。方法回顾性分析2004年1月至2009年12月在沈阳医学院附属奉天医院心血管内科住院并确诊的45岁及以下冠心病患者165例,分为急性心肌梗死(AMI)组和非AMI组。对两组患者的相关临床资料及危险因素进行统计分析。结果 AMI组吸烟史比例、男性比率、血浆纤维蛋白原及D-二聚体均高于非AMI组,差异有统计学意义(P<0.05),两组的血脂异常率、血小板计数(PLT)、血小板压积、凝血酶原时间(PT)、国际标准化比值(INR)和活化部分凝血活酶时间(APTT)的差异无统计学意义。结论吸烟、男性性别、血脂水平异常是早发冠心病重要危险因素;血浆纤维蛋白原水平增高对于预测早发冠心病心肌梗死可能具有一定的临床意义。

Objective To investigate the differences of risk factors in premature coronary heart disease patients with acute myocardial infarction and non - acute myocardial infarction. Methods For retrospective ease analysis, we enrolled totally 165 inpatients with coronary heart disease （ ≤45 years of age ） of Department of Cardiology, Fengfian Hospital affiliated to Shenyang Medical College between January 2004 and December 2009. Patients were divided into acute myocardial infarction and non- acutemyocardial infarction group. Clinical data and risk factors were analyzed statistically according to the two groups. Results Risk factors such as proportion Of smoking history, male ratio, plasma fibrinogen levels and D - dimer lev- els of acute myocardial infarction group were higher than the non - acute myocardial infarction group, the difference was statistically significant （ P 〈 0.05 ）. In contrast, differences of dyslipidemia rate, the PLT, platelet hematocrit, PT, INR and APTT of the two groups were not statistically significant. Conclusion Smoking, mankind, abnormal blood lipid levels are important risk factors for premature coronary heart disease ;increased plasma fibrinogen levels may serve as risk predictor for acute myocardial infarction of premature coronary heart disease.