尿微量白蛋白与妊娠期高血压疾病早期肾损伤关系的研究

Study on relationship between urinary albumin and early renal damage of pregnancy induced hypertension

目的探讨尿微量白蛋白(尿mALB)与妊娠期高血压疾病患者早期肾损害的关系,评价临床诊断价值。方法采用免疫散射比浊法检测60例孕25～42周孕妇尿微量白蛋白(尿蛋白定性均为阴性),其中30例妊娠期高血压孕妇作为观察组,另30例正常孕妇为对照组。结果观察组尿微量白蛋白(26.01±7.28)mg/L,超过参考值阳性率60.00%。对照组尿微量白蛋白(8.17±2.98)mg/L,超过参考值阳性率10.00%。两组比较有统计学差异(P<0.05)。结论妊娠期高血压疾病早期肾损伤患者尿微量白蛋白明显升高,检测尿微量白蛋白可用于及早发现妊娠期高血压疾病的早期肾损伤,对及时干预,阻止病情发展有其重要的临床意义。

Objective To investigate the relationship between urinary albumin（urine mALB） and early renal damage in patients with pregnancy-induced hypertension,evaluation of clinical diagnostic value.Methods Immunohistochemical nephelometry detected of microalbuminuria 60 cases of pregnant women 25 to 42 weeks（urinary protein characterization were negative）,of which 30 cases of pregnancy hypertension as the observation group,and 30 normal pregnant women as control group.Results In obsevrvation group,the urinary albumin（26.01±7.28） mg/L,the positive rate than the reference value of 60.00%.In control group,urinary albumin（8.17±2.98） mg/L,the positive rate than the reference value 10.00%.Significant difference between the two groups significant（P0.05）.Conclusions Urinary albumin in pregnancy induced hypertension patients with early renal injury was significantly higher urinary albumin,can be used for early detection of early renal damage of pregnancy-induced hypertension,has important clinical significance for timely intervention and prevent progression of the disease.