生活方式和膳食因素与高尿酸血症关系的病例对照研究

Case control study of the influence of diet and lifestyle on hyperuricemia

目的探讨生活方式及膳食因素中存在的高尿酸血症的危险因素。方法采用病例对照研究,采用logistic回归模型筛选高尿酸发病的危险因素。结果豆类、鱼虾类、奶类、汤类、坚果类这5大类是高尿酸发病的危险因素,饮酒史OR=3.972,甜食OR=2.011,维生素C OR=0.657、饮茶OR=0.409,这4个因素与高尿酸血症的发生有关系。其中饮茶、补充维生素C与高尿酸的发病成负相关。结论减少饮酒,少食海鲜类和豆类富含嘌吟的食物,补充维生素C,多饮茶可以预防或者减少高尿酸血症的发生。

Objective To study the risk factors existing in diet and lifestyle causing hyperuricemia.Methods Case control study was conducted.The value of BUA（Blood Uric Acid） was tested.The Conditional Logistic Regression was used to select the risk factors of hyperuricemia.Results In dietary factors,beans,fish and shrimp,milk,soup,nuts were high risk factors for hyperuricemia.In lifestyle,drinking OR=3.972,sweet OR=2.011,vitaminC OR=0.657,tea OR=0.409,these four factors were positive correlated with hyperuricemia.Tea and vitaminC are negatively correlated with the hyperuricemia.Conclusions Reducing drinking alcohol and the consumption of seafood and soybean which full of purine,supplying vitaminC,drinking tea can reduce the value of BUA of hyperuricemia.