参麦注射液联合维生素C治疗小儿病毒性心肌炎的疗效及对血肌钙蛋白T的影响

Therapeutic Efficacy of Shenmai Injection Combined with Vitamin C in the Treatment of Viral Myocarditis in Children and the Change of cTnT

目的:探讨参麦注射液联合维生素C对小儿病毒性心肌炎的疗效及其对血肌钙蛋白T(cTnT)的影响。方法:选择我院2008年1月-2010年6月期间收治的120例小儿病毒性心肌炎患者,随机分为2组,对照组62例,采用绝对卧床休息、抗心律失常、抗病毒、营养心肌代谢药物等综合治疗;观察组58例,在对照组的基础上采用参麦注射液+维生素C治疗。2组疗程均为2周。观察2组的临床疗效,并在治疗前、后测定cTnT。结果:治疗后,观察组总有效率(89.65%)明显高于对照组(67.74%),差异有统计学意义(P<0.05)。2组治疗后cTnT水平均显著低于治疗前,差异有统计学意义(P<0.05)。治疗后,2组cTnT比较,差异有统计学意义(P<0.05),观察组显著低于对照组。2组均未见明显不良反应发生。结论:参麦注射液联合维生素C治疗小儿病毒性心肌炎效果良好,并可能通过影响血中cTnT的变化而发挥作用。

OBJECTIVE： To discuss the therapeutic efficacy of Shenmai injection combined with vitamin C in the treatment of viral myocarditis in children, and to observe its related mechanism. METHODS： The clinical information of 120 children with viral myocarditis from Jan. 2008 to Jun. 2010 was retrospectively analyzed. They were randomly divided into 2 groups. 62 cases in con- trol group were treated with bed rest, anti-arrhythmia, antiviral, myocardial nutritional metabolism drug and so on. 58 cases in ob- servation group were additionally given Shenmai injection and vitamin C on the basis of control group for a treatment course of 2 weeks. The therapeutic efficacy was observed and the change of cTnT was determined before and after treatment. RESULTS： The total effective rate of observation group （89.65%） was obviously higher than that of control group （67.74%）, the difference had statistical significance （P〈0.05）. The level of cTnT was obviously decreased after treatment in the same group, the difference had statistical significance （P〈0.05）. After treatment, the difference of cTnT had statistical significance （P〈0.05）. There was no ADR found in 2 groups. CONCLUSION： Shenmai injection combined with vitamin C is effective in the treatment of pediatric viral myo- carditis and achieves good effect by affecting the change of cTnT.