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难治性原发性胆汁性肝硬化的治疗 被引量：9

Therapy for refractory primary biliary cirrhosis
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摘要 原发性胆汁性肝硬化（primarybiliarycirrhosis，PBC）是一种肝脏特异的慢性进行性自身免疫性疾病，女性发病率较高，以肝内胆汁淤积为特征，血清多种自身免疫性抗体阳性，常并发其他自身免疫性疾病。
作者 韩英 朱疆依
机构地区 第四军医大学西京消化病医院肝病科
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2012年第5期330-332,共3页 Chinese Journal of Hepatology
关键词 肝硬化 胆汁性 治疗 熊去氧胆酸 Liver cin＇hosis, biliary Thempy, Ulsodeoxycholic acid
分类号 R575.2 [医药卫生—消化系统]
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参考文献19

  • 1Corpechot C, Abenavoli L, Rabahi N, et al. Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis. Hepatology, 2008, 48: 871-877.
  • 2Pares A, Caballeria L, Rodes J. Excellent long-term survival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic acid. Gastroenterology, 2006, 130: 715-720.
  • 3Kuiper EM, Hansen BE, de Vries RA, et al. Improved prognosis of patients with primary biliary cirrhosis that have a biochemical response to ursodeoxyeholie acid. Gastroenterology, 2009, 136: 1281-1287.
  • 4Miyaguchi S, Ebinuma H, Imaeda H, et al. A novel treatment for refractory primary biliary cirrhosis? Hepatogastroenterology, 2000, 47: 1518-1521.
  • 5Heathcote EJ. Management of primary biliary cirrhosis. The American Association for the Study of Liver Diseases practice gudelines. Hepatology, 2000, 31: 1005-1013.
  • 6Czaja AJ, Freese DK; American Association for the Study of Liver Disease. Diagnosis and treatment of autoimmune hepatitis. Hepatology, 2002, 36: 479-497.
  • 7Chazouill&es O, Wendum D, Serfaty L, et al. Long term outcome and response to therapy of primary biliary cirrhosis-autoimmune hepatitis overlap syndrome. J Hepatol, 2006, 44: 400-406.
  • 8Angulo P, Jorgensen RA, Keach JC, et al. Oral budesonide in the treatment of patients with primary biliary cirrhosis with a suboptimal response to ursodeoxycholic acid. Hepatology, 2000, 31: 318-323.
  • 9Nakamuta M, Fujino T, Yada R, et al. Therapeutic effect of bezafibrate against biliary damage: a study of phospholipid secretion via the PPARalpha-MDR3 pathway. Int J Clin Pharmacol Ther, 2010, 48: 22-28.
  • 10Delerive P, De Bosscher K, Besnard S, et al. Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1. J Biol Chem, 1999, 274: 32048- 32054.

同被引文献76

  • 1中华医学会肝病学分会,中华医学会感染病学分会.慢性乙型肝炎防治指南[J].传染病信息,2005,18(z1):1-12. 被引量：466
  • 2中华医学会肝病学分会脂肪肝和酒精性肝病学组.酒精性肝病诊疗指南[J].中国肝脏病杂志（电子版）,2010,2(4):49-53. 被引量：384
  • 3闫惠平,庄辉,刘燕敏,冯霞,檀玉芬,刘妍,张欣,赵春惠.原发性胆汁性肝硬化患者的免疫学特点分析[J].中华肝脏病杂志,2005,13(1):12-16. 被引量：49
  • 4Sanchez EQ,Levy MF,Goldstein RM,et al.The changing clinical presentation of recurrent primary biliary cirrhosis after liver transplantation[J].Transplantation,2003,76(11):1583-158.
  • 5Yusoff IF, House AK,De Boer WB,et al.Disease recurrence after liver transplantation in Western Australia[J].J Gastroenterol Hepatol, 2002,17(2):203-207.
  • 6陈灏珠,林果为,王吉耀实用内科学[M].14版北京:人民卫生出版社:2013:9.
  • 7Kim K A, Jeong S H. The diagnosis and treatment of pri- mary biliary cirrhosis [ J]. Korean J Hepatol, 2011,17 (3) :173-179.
  • 8Liu H, Liu Y, Wang L, et al. Prevalence of primary bili- ary cirrhosis in adults referring hospital for annual health check-up in Southern China [ J ]. BMC Gastroenterol, 2010,10(1) :100.
  • 9Lindor K D, Gershwin M E, Poupon R, et al. Primary biliary cirrhosis [ J ]. Hepatology, 2009,50 ( 1 ) : 291-308.
  • 10Prince M I, James O F. The epidemiology of primary bili- ary cirrhosis [ J]. Clin Liver Dis, 2003,7 (4) : 795-819.

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中华肝脏病杂志
2012年 第5期

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