单唾液酸四己糖神经节苷脂应用于手足口病并发脑炎的疗效观察

Observation of therapeutic effect of GM-1 for HFMD combine with encephalitis

目的:观察单唾液酸四己糖神经节苷脂(GM-1)治疗手足口病合并脑炎的疗效及安全性。方法:将本院2010年4月至11月收治的139例手足口病合并脑炎患儿,随机分为治疗组81例、对照组58例。两组均给予静脉用丙种球蛋白、甲基强的松龙及甘露醇、呋塞米降颅内压、抗病毒治疗等。在此基础上治疗组加用GM-1 20mg加入5%GS 50mL静脉滴注,10～14d为一疗程。结果:治疗组肌张力、惊跳、嗜睡、呕吐恢复正常时间分别为(8.0±3.2)、(4.2±1.0)、(3.6±1.3)、(2.8±0.8)d,对照组分别为(10.3±3.8)、(4.8±1.3)、(4.2±1.3)、(3.2±1.0)d,差异均有统计学意义(P<0.05)。两组临床疗效比较,治疗组显效43例,有效29例,无效9例,总有效率88.89%;对照组显效21例,有效22例,无效15例,总有效率74.14%,治疗组疗效优于对照组(P<0.05)。结论:GM-1治疗儿童手足口病合并脑炎可较快减轻临床症状,提高治愈率,且未见明显不良反应,安全有效。

AIM： To observe the therapeutic effect of HFMD combine with encephalitis by monosialoteterahexosyl ganglioside（GM-1）.METHODS： 139 cases in our hospital from April 2010 to November 2010 were randomly divided into two groups,one with 81 cases as a treatment group and another with 58 cases as control group.All of the two groups were accepted the treatment of GG＋MePr＋MNT＋ FSM i.v.within antiviral therapy.The treatment group was added ivgtt of the 5%GS 50 mL with GM-1 20 mg,10-14 days as one course of treatment.RESULTS：The times of Symptoms improved after treatment,including muscle tension,startle,lethargy,vomiting of treatment group were（8.0±3.2）,（4.2±1.0）,（3.6±1.3）,（2.8±0.8） d,control group were（10.3±3.8）,（4.8±1.3）,（4.2±1.3）,（3.2±1.0） d,each indicator had statistically significant difference（P0.05）.In treatment group,excellence 43 cases,utility 29 cases,ineffective 9 cases,the total effective rate was 88.89%.In control group,excellence 21 cases,utility 22 cases,ineffective 15 cases,the total efficiency rate was 74.14%.The trerapeutic effect of treatment group was better than that of control group（P0.05）.CONCLUSION： GM-1 can rapidly relieve the clinical symptoms,improve the recovery rate,and has no significant adverse reactions,is safe and effective.