孟鲁司特对毛细支气管炎患儿尿白三烯E4水平的影响

Effect of montelukast on the level of urine leukotriene E4 in children with bronchiolitis

目的:观察孟鲁司特对毛细支气管炎患儿尿白三烯E4(LTE4)水平的影响。方法:将69例急性期毛支患儿随机分为孟鲁司特治疗组和常规治疗组,对两组进行疗效比较及尿LTE4测定;同时对48例缓解期毛支分别予孟鲁司特和丙酸氟替卡松吸入,1个月后观察两组的尿LTE4水平变化。结果:孟鲁司特组气急消失时间、体征消失时间和住院时间均较常规组缩短(P<0.01)。毛支治疗前,孟鲁司特组和常规组尿LTE4水平比较无统计学差异(P>0.05),与对照组比较,两者均明显升高(P<0.01);治疗后,孟鲁司特组尿LTE4水平较常规组明显下降,差异有统计学意义(P<0.01),与对照组比较无统计学意义(P>0.05);而常规组尿LTE4水平仍高于对照组(P<0.01)。毛支缓解后,分别予孟鲁司特和丙酸氟替卡松吸入治疗1个月,后孟鲁司特组尿LTE4水平明显低于激素吸入组。结论:孟鲁司特可有效降低毛支患儿急性期及缓解期尿LTE4水平,改善毛支患儿的临床症状。

AIM： To observe the effects of montelukast on the level of urine LTE4 in children with bronchiolitis.METHODS： Sixty-nine cases of children with bronchiolitis were divided into two groups randomly,a group with montelukast treatment and a group with regular treatment.The treatment effects and the urine LTE 4 level of the two groups were compared.At the same time,48 cases of children with bronchiolitis in remission were given montelukast or fluticason inhalation,the changes of level on urine LTE4 of the two groups were observed.RESULTS：The period to the disappearance of breath shortness,the disappearance of physical symptoms and the length of stay in hospital of montelukast group were shorter than those in the group with regular treatment（P0.01）.Before the therapy,there was no significant difference of urine LTE4 between the groups of montelukast treatment and regular treatment（P0.05）,the level of urine LTE4 in both group were increased compared with the control group（P0.01）.After therapy,the urine LTE4 level of the montelukast treatment group was decreased obviously compared with those of the regular treatment group（P0.01）.There was no significant difference compared with the comparison group（P0.05）;while the urine LTE4 level of group with regular treatment was higher than those of control group（P0.01）.After the remission of bronchiolitis,the children were given with montelukast or fluticasone propionate inhalation for a month and there was obviously lower level urine LTE4 in the group montelukast treatment than the group with hormone treatment.CONCLUSION： Montelukast can effectively decrease the levels of urine LTE4 in the acute phrase and remission and improve the clinical symptoms of children with bronchiolitis.