复合催化剂一步催化合成富马酸二甲酯

CATALYTIC SYNTHESIS OF DIMETHYL FUMARATE WITH COMPOSITE CATALYSTS

实验以马来酸酐和甲醇为原料,用玻璃球负载纳米级SO42-/TiO2固体超强酸作酯化催化剂,硫脲为异构化试剂,一步催化合成富马酸二甲酯,考察了富马酸二甲酯的合成条件和催化剂的重复使用效果。最佳合成工艺条件为:n(马来酸酐)∶n(甲醇)=1∶6.0,超强酸用量2.8%,硫脲用量3.5%,回流反应3.0h,富马酸二甲酯收率为95.6%;催化剂重复使用5次富马酸二甲酯收率为89.3%。

The synthesis of dimethyl fumarate（DMF） by esterification reaction of maleic anhydride and methanol catalyzed by glass ball supported nano-sized SO2-4/TiO2 solid superacid and isomerization catalyzed by sulfourea,was studied.The esterification conditions and the effects of the repeated use of the catalyst were studied.The optimum synthesis conditions were found as follows： n（maleic anhydride）n（methanol）=1∶6.0,weight of the solid superacid=2.76%,weight of sulfourea=3.45%,the reaction time 3.0 h.The results showed that the yield of DMF could reach 95.6%,and the yield of DMF was 89.3% after the catalyst being used repeatedly for 5 times.