肝癌组织中粘附分子、血管内皮生长因子和基质金属蛋白酶-9的表达及临床意义

Expression and clinical significance of CD44v6, VEGF and MMP-9 in hepatocellular carcinoma tissae

目的探讨粘附分子（CD44v6）、血管内皮生长因子（VEGF）和基质金属蛋白酶-9（MMP-9）在肝癌组织中的表达及其临床意义。方法采用免疫组化sP法检测60例肝癌组织q-CD44v6、VEGF和MMP-9表达情况，并以20例正常肝组织作为对照。结果肝癌组织中CD44v6、VEGF和MMP-9表达显著高于正常肝组织（P〈0．05）。肝癌患者中Ⅲ-Ⅳ期、淋巴结转移患者的CIM4v6、VEGF和MMP-9阳性表达率分别高于I～Ⅱ期和无淋巴结转移患者（P〈0．05）。结论肝癌组织中CD44v6、VEGF和MMP-9的表达水平明显升高，它们在肝癌的浸润转移中起到了重要的作用，可作为反映肝癌进展的生物学指标。

Objective To investigate the expression and clinical significance of CD44v6, VEGF and MMP-9 expression in hepatocellular carcinoma. Methods The expression levels of CD44v6, VEGF and MMP-9 were measured by immunohistochemistry in the reseeted specimens from 60 pgtients with hep- atocellular carcinoma and 20 normal liver tissues （controls）. Results The positive rates of CD44v6, VEGF and MMP-9 were significantly higher in the hepatocellular carcinoma patients than those in controls （P 〈 0. 05）. The positive rates of CD44v6, VEGF and MMP-9 in Ⅲ-Ⅳ stage were significantly higher than those of patients in Ⅰ-Ⅱstage tumor （P 〈 0.05 ）. The positive rates of CIM4v6, VEGF and MMP-9 in lymph node metastasis tumor were significantly higher than those of patients in non metastasis tumor （P 〈 0.05）. Conclusions CD44v6, VEGF and MMP-9 expression in hepatocellular carcinoma increases markedly and plays an important role in progression of hepatocellular carcinoma.