比索洛尔治疗80岁以上慢性心力衰竭患者的疗效观察

Effect of bisoprolol on more than 80-year-old patients with chronic heart failure

目的观察比索洛尔治疗80岁以上慢性心力衰竭患者的疗效和安全性。方法选择老年慢性心力衰竭患者108例，老年组（60—79岁）58例，高龄组（80岁及以上）50例，均按照指南给予优化药物治疗，B受体阻滞剂均选用比索洛尔，观察两组患者治疗前后心脏结构、功能的改变以及不良反应。结果治疗后两组左室射血分数较治疗前明显改善，老年组提高5％，高龄组提高4％，两组治疗后左室射血分数改善程度组内比较差异均有统计学意义（P〈0．01）。两组治疗后心力衰竭症状均较治疗前改善，NYHA分级两组治疗前后组内比较差异有统计学意义（P〈0．01）。不良事件发生率老年组和高龄组分别为38％和46％，组间比较差异无统计学意义（P〉0．05）。结论比索洛尔治疗80岁以上慢性心力衰竭患者安全、有效。

Objective To observe the efficacy and safety of bisoprolol on more than 80-year-old patients with chronic heart failure （CHF）. Methods One hundred and eight old patients with chronic heart failure were involved in the study and were divided into the elder group（ age 〉 60 and ≤79, n = 58 ） and the very elder group（ age 〉180 years, n = 50）. All patients were treated with optimal pharmacotherapy according to guideline recommendations, bisoprolol was given to all patients as [3-blocker, changes of heart size, cardiac function and adverse ＇events were observed. Results The LVEF improved significantly after treatment, 5% for elder group, and 4% for very eider group. There was significantly difference between the two groups（ P 〈 0. 01 ）. The symptoms of chronic heart failure in both groups were improved, there were differences between before and after treatment （P 〈 0. 01 ）. No significant difference was found on adverse events between the elder group （38%） and the very elder group （46%）. Conclusions Bisoprolol is safe and effective for treating more than 80-year-old patients with chronic heart failure.