全血中5种重金属与女性乳腺癌发病的相关性研究

Study on the Correlation between Five Kinds of Heavy Metals in Whole Blood and Breast Cancer in Women

目的探讨5种重金属Cr、Ni、Cu、Zn、Hg与女性乳腺癌发病的关系。方法 2010年11月-2011年5月采集43例乳腺癌患者及43例同期住院非乳腺癌、非内分泌疾病的对照患者的全血标本,采用电感耦合等离子体质谱仪(ICP-MS)进行Cr、Ni、Cu、Zn、Hg重金属含量测定。结果乳腺癌患者全血中Cr、Cu含量明显高于对照组(t值分别为2.104、1.834,P<0.05);Zn、Ni含量与对照组差异无统计学意义(t值分别为0.333、1.095,P>0.05);对照组全血中未检出Hg。消除流产次数混杂因素影响后,Cu高暴露组乳腺癌患病风险是低暴露组的4.625倍;消除是否使用杀虫剂混杂因素影响后,Cu高暴露组乳腺癌患病风险是低暴露组的6.531倍。结论重金属Cu的高暴露可能增加乳腺癌的发病风险。

Objective To explore the relationship between five kinds of heavy metals and breast cancer. Methods A case-control study was conducted. A total of 43 newly diagnosed female patients with breast cancer from November 2006 to November 2007 were selected as the cases. A total of 43 controls were identified at the same hospital, with the exception of gynecological, endocrinological and oncological diseases. Whole blood of cases and controls were collected, and the concentrations of heavy metals（Cr, Ni, Cu, Zn, Hg） were measured by inductively coupled plasma mass spectrometry（ICP-MS）. Results The level of Cr and Cu was significantly higher in the patients with breast cancer compared with the controls. Compared with low exposure group（Cu〈818.80 μg/L）, a significant elevated risk of breast cancer was observed for high exposure （Cu≥818.80 μg/L）, OR values eliminated by times of abortion and history of pesticide using were 4.625 and 6.531.Conclusion High Cu exposure is significantly associated with increasing breast cancer risk.