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PBRM1和P53与肾癌的相关性研究

Analysis on the correlation between PBRM1 and p53 with renal cell carcinoma
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摘要 目的探讨PBRMl和P53蛋白在肾癌中的表达和临床意义。方法应用免疫组化方法对66例肾癌组织进行PBRM1和p53蛋白检测。结果在肾癌组织中PBRMI和t＇53蛋白表达阳性率分别为62．1％和39．4％。PBRMl表达与肾细胞癌分级、分期相关（P〈0．05），与肾癌的病理类型无关（P〉0．05）。P53表达与肾癌的病理类型、分级、分期无关（P〉0．05）。结论PBRMl表达水平随着。肾癌组织的病理分级和临床分期的增高而增高，可能与肿瘤的生物学行为有一定关系。P53表达在肾癌生物学行为不具有重要意义。 Objectives To study the expression of PBRMI and P53 in renal cell carcinoma （RCC） and its clinical significance. Methods The protein of PBRM1 and P53 was examined in 66 cases of RCC immnnohis- tochemistry. Results The positive rate of expression of PBRM1 and P53 were 62.1% and 39.4% （ P 〉 0.05 ）. Conclusions The expression level of PBRM1 increased markedly with the clinical stage or clinical grade of RCC and it could be related to the biological behavior of neoplasms. But p53 plays an unimportant role in RCC.
作者 赵小东 陈一戎 车团结
机构地区 兰州大学第一临床医学院泌尿外科
出处 《国际泌尿系统杂志》 2012年第3期310-312,共3页 International Journal of Urology and Nephrology
关键词 肾肿瘤 蛋白质P53 免疫组织化学 Kidney Neoplasms Protein 1753 lmmunohistochemistry
分类号 R737.11 [医药卫生—肿瘤]
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参考文献6

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二级参考文献20

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国际泌尿系统杂志
2012年 第3期

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