瘫痪患者医院感染情况研究及抗菌药物治疗方案探讨

Investigation on Nosocomial Infections in Paralytic Patients and Exploration of Antibiotics Therapy

目的分析我院瘫痪患者医院感染的现状及抗生素耐药情况,为临床治疗及抗生素的合理应用提供科学依据。方法选取2010年1月～2011年6月间我院收治的瘫痪患者医院感染病例,对其感染部位细菌学和耐药情况进行综合分析。结果瘫痪患者的医院感染发病率较高,感染部位以呼吸道、泌尿道为主。致病菌以铜绿假单胞菌、肺炎克雷白杆菌、大肠埃希菌等革兰阴性菌感染为主,致病菌有较强的耐药性,并呈高度交叉耐药的特点。结论做好细菌耐药性监测,根据细菌耐药试验及PK/PD(药动学/药效学)理论优化抗菌药物治疗方案对于临床治疗有重要意义。

OBJECTIVE To pave the way for clinical therapy and reasonable use of antibiotics through investigation on the current status of nosocomial infections and antibiotics resistance in paralytic patients. METHODS Comprehensive analyses on the bacteriology of infection sites and drug resistance were performed in the hospitalized paralytic patients of our hospital from Jan. ,2010 to Jun. , 2011. RESULTS The incidence of nosocomial infections in the paralytic patients was high, and most of the infections were found in lower respiratory tract and urinary tract. The main pathogens were gram -negative bacteria,but the pathogens were highly resistant with significant cross resistance. CONCLUSION It is important for clinical treatment to monitor the drug resistance of bacteria and optimize antibiotics therapy according to antimicrobial susceptibility test and PK/PD theories.