针灸治疗麻痹性斜视系统评价

Acupuncture Treatment in Paralytic Strabismus:A Systematic Review

目的:评价针灸治疗麻痹性斜视的临床疗效及安全性。方法:计算机检索Cochrane Library(Issue 1,2011)、PubMed(1980—2011.7)、MEDLINE(1966—2011)、Ovid循证医学数据库(1991—2011),中国生物医学文献数据库(CBMdisc,1978—2011.7)、中国期刊全文数据库(CNKI,1979—2011.7)、维普期刊全文数据库(VIP,1989—2011.7)和万方数据资源系统(1983—2011.7),同时手工检索4种中医杂志,检索时间均为2010.1—2011.8,语言限于中英文,收集针灸治疗麻痹性斜视的临床随机对照试验(RCT),参照Cochrane系统评价员手册5.1.0推荐的对偏倚风险的评价工具进行文献质量评价,并采用RevMan 5.0软件进行Meta分析。结果:最终纳入5个RCT,均为低质量研究,共301例患者,Meta分析结果显示,两组有效率的差异有统计学意义[RR=1.30,95%C(I1.09,1.54)],针灸配合药物治疗麻痹性斜视的疗效优于单纯使用药物。结论:针灸治疗麻痹性斜视有一定疗效,但由于纳入试验质量均较低,仍需高质量的随机对照试验来确定针灸治疗麻痹性斜视的疗效。

Objective：To evaluate the efficacy and safety of acupuncture for paralytic strabismus.Methods：We electronically searched Cochrane Library（Issue l,2011）,PubMed（1980 to Jul.2011）,MEDLINE（1966 to 2011）,Ovid EBM Database（1991 to 2011）,CBMdisc（1978 to Jul.2011）,VIP（1989 to Jul,2011）,CNKI（1979 to Jul,2011）and Wangfang Database（1983 to Jul.2011）as well as handsearching four traditional Chinese medicine journals to obtain randomized controlled trials（RCTs）about acupuncture for paralytic strabismus.Quality assessment was conducted by the Cochrane Handbook for Systematic Reviews of Interventions 5.1.0.Meta-analyses were performed for the results of homogeneous studies using RevMan 5.0 software.Results：5 RCTs involving 301 patients met the inclusion criteria.The meta analysis of five trials showed that acupuncture was superior in paralytic strabismus with RR=1.30,and 95%CI was 1.09 to 1.54.Conclusions：Acupuncture is a probably effective treatment method for paralytic strabismus.However,it still needs high qualify studies to reevaluate the effectiveness of acupuncture treatment for paralytic strabismus because of the 5 included low quality trials in current reports.