摘要
目的:合成牛蒡苷元的氨解衍生物N-苯甲基-2-(4'-羟基-3'-甲氧基苯甲基)-3-(3'',4''-二甲氧基苯甲基)丁酰胺。方法:本实验采用氨解的方法对牛蒡苷元的内酯环进行结构修饰,牛蒡苷元和苄胺溶液反应合成氨解衍生物。结论:通过对合成工艺条件进行较为详细的考察,确定最佳工艺条件。
Objective:N-benzyl-3-(3'',4''-dimethoxybenzyl)-4-hydroxyl-2-(3'-hydroxoy-4'-methoxybenzyl)butanamide,ammonoylsis derivative of arctigenin was yielded.Method:Structure modification in γ-lactone ring of arctigenin was carried out.The ammonolysis derivative was synthesized by treating arctigenin and benzylamine solution.Conclusion:The art of the synthesis process was investigated in detail to determine the optimum process conditions.
出处
《辽宁中医药大学学报》
CAS
2012年第6期53-54,共2页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家重大新药创制项目(2009ZX09103-423)