牛蒡苷元氨解衍生物的合成

Synthesis of Arcitgenin Ammonolysis Derivative

目的:合成牛蒡苷元的氨解衍生物N-苯甲基-2-(4'-羟基-3'-甲氧基苯甲基)-3-(3'',4''-二甲氧基苯甲基)丁酰胺。方法:本实验采用氨解的方法对牛蒡苷元的内酯环进行结构修饰,牛蒡苷元和苄胺溶液反应合成氨解衍生物。结论:通过对合成工艺条件进行较为详细的考察,确定最佳工艺条件。

Objective：N-benzyl-3-（3＇＇,4＇＇-dimethoxybenzyl）-4-hydroxyl-2-（3＇-hydroxoy-4＇-methoxybenzyl）butanamide,ammonoylsis derivative of arctigenin was yielded.Method：Structure modification in γ-lactone ring of arctigenin was carried out.The ammonolysis derivative was synthesized by treating arctigenin and benzylamine solution.Conclusion：The art of the synthesis process was investigated in detail to determine the optimum process conditions.