男性血糖调节受损阶段血清性激素水平变化分析

Analysis on Changes of Serum Sex Hormone Levels in Males with Impaired Glucose Regulation Stage

目的:观察男性血糖调节受损阶段(IGR)血清总睾酮(T)、雌二醇(E2)水平变化并用相关中医理论加以论述。方法:采用化学发光法分别对男性IGR、男性2型糖尿病(T2DM)患者和男性健康体检者各45名进行血清T、E2水平测定并将测定结果比较。结果:IGR组和T2DM组分别与健康对照组比较血清T明显降低(P<0.05),而E2水平明显升高(P<0.05),均有统计学意义;T2DM组与IGR组比较血清T亦明显降低(P<0.05),E2水平亦明显升高(P<0.05),亦有统计学意义。结论:男性在IGR阶段即存在性激素分泌功能的紊乱,若此期加以重视并有效干预,可能减少或减慢发展成糖尿病,一部分IGR可以逆转为正常糖调节状态,则T、E2水平有希望恢复正常水平。

Objective：Compare the levels of serum total testosterone（T）and estradiol（E2）in males with impaired glucose regulation（IGR）,moreover discuss it in traditional Chinese medicine.Methods：Male with IGR,male patients with T2DM and male healthy subjects,45 in each group,were respectively measured serum T and E2 levels by chemiluminescence immunoassay.Results：IGR group and T2DM group were compared with healthy control group respectively and T levels were significantly reduced（P0.05）while E2 levels were significantly increased（P0.05）.Conclusion：Males with IGR stage may develop dysfunction of sex hormone secretion.If this period is paid more attention to and given effective interventions,it may reduce or slow down the development of diabetes.Part of the IGR can be reversed to normal glucose regulation status and T and E2 levels may return to normal levels.