脑心通胶囊治疗血管性痴呆

Effect of Naoxintong Capsule in Treating Vascular Dementia

目的:观察脑心通胶囊治疗血管性痴呆(vascular dementia,VD)的临床疗效。方法:48例VD患者随机分为两组,治疗组24例,采用脑心通胶囊治疗;对照组24例,采用都可喜和尼莫地平治疗。治疗前后进行简易精神状态量表(MMSE)、长谷川痴呆量表(HDS)、日常生活能力量表(ADL)等评分,观察并比较两组临床疗效、治疗前后各量表积分值变化情况。结果:治疗组总有效率为87.5%,对照组总有效率为62.5%,两组比较,差异有统计学意义(P<0.05)。治疗后两组MMSE、HDS、ADS量表评分均较治疗前有明显改善(P<0.01);治疗组改善MMSE、HDS量表评分情况优于对照组(P<0.05),而ADS量表评分改善的两组比较,差异无统计学意义(P>0.05);治疗后治疗组血液流变学各指标均较治疗前明显改善(P<0.01),与对照组比较差异有统计学意义(P<0.01或P<0.05)。结论:脑心通胶囊可有效改善VD患者的智力和日常生活能力。

Objective：To observe the effect of Naoxintong Capsule in treating vascular dementia（vascular dementia,VD） clinical efficacy.Methods：48 cases of VD were randomly divided into two groups,24 cases in the treatment group,using Naoxintong Capsule in treatment of 24 cases of the control group,Duxiland nimodipine in the treatment o.Before and after treatment were Mini-Mental State Examination（MMSE）,Kyohko Hasegawa Dementia Scale（HDS）,ability of daily living scale（ADL）,score,we observed and compared the clinical outcomes of the two groups,before and after each treatment scale integral value changes.Results：The total effective rate in the treatment group control group was 87.5%,total effective rate was 62.5%,in two groups,the difference was statistically significant（P0.05）.In two groups after the treatment,MMSE,HDS,ADS score than before treatment has improved significantly（P0.01）;the treatment group improved MMSE,HDS scores than those in the control group（P0.05）,while ADS scale score improvement between the two groups,the difference was not statistically significant（P0.05） after treatment in treatment group;blood rheology indexes were markedly improved than those before treatment（P0.01）,compared with the control group,the difference was statistically significant（P0.01 or P0.05）.Conclusion：Naoxintong capsule can improve VD patients with intelligence and ability of daily life.