仁和正胃胶囊对胃液分泌功能影响的实验研究

Experimental study on the effects of Zhengwei capsules on the secretion of gastric juice function in rats

目的研究正胃胶囊对胃液分泌的影响。方法制备正常大鼠胃液分泌及组胺刺激大鼠胃液分泌2个模型,正胃胶囊与对照组中药制剂(胃康灵胶囊、胃泰颗粒)、西药制剂(维U颠茄铝胶囊、铝碳酸镁片)比较,测定正胃胶囊的制酸止痛作用。结果正胃胶囊能显著抑制胃蛋白酶活力,对胃液的pH值有明显升高作用;对组胺刺激的胃液分泌量增加有明显的抑制作用;对正常大鼠胃液分泌量仅有轻度抑制作用。结论正胃胶囊在抑制胃蛋白酶活性、降低胃液pH值、抑制胃液过量分泌等有明显的临床应用优势。

Objective To study on the effects of Zhengwei capsules on the secretion of gastric juice function in rats.MethodsBy determined the secretion of gastric juice of normal rats and histamine stimulation rats.The inhibition of gastric acid secretion and analgesia of Zhengwei capsules were investigated.ResultsZhengwei capsules can significantly inhibit the activity of pepsin,significantly increased the pH value of gastric juice,significantly inhibited the increase of gastric acid secretion of histamine stimulation rats,only mild inhibited the gastric acid secretion of normal rats.ConclusionAs an integrated Chinese and western stomachic,Zhengwei capsules have significant clinical advantages in the inhibition of pepsin activity,reduce the pH value of gastric juice,inhibition of excessive secretion of gastric juice.