微透析技术在靶组织局部药物浓度检测中的应用

Application of microdialysis technique in monitoring local drug concentration in tissue-targeted

微透析技术是一项越来越被广泛使用的在体研究技术,其遵循透析原理,以探针为基础取样,可连续检测局部组织细胞外液的药物浓度,能满足常规的药代动力学/药效学(PK-PD)研究。本文就其在靶组织局部药物浓度检测中的应用作一简要介绍。

Microdialysis,based on the dialysis principle,is a new probe-based sampling technique in vivo which can continuous monitoring drug concentration of extracellular fluid in local tissues during several hours and days.It satisfies regulatory requirements for pharmacokinetic-pharmacodynamic（PK-PD） studies,and could provide scientific basis for the development of new drugs and clinical rational drug use.This review presents the monitoring local drug concentration in tissue-targeted by microdialysis technique.