Pd/C-甲酸铵在催化氢转移氢解反应中的应用

Application of Pd/C-(ammonium formate) in Catalytic Transfer Hydrogenolysis

以Pd/C-甲酸铵为催化剂,沙美特罗的重要中间体1-(2,2-二甲基-4H-1,3-苯并二氧芑-6-基)-2-(2-羟基-1-苯乙氨基)乙醇通过催化氢转移氢解完成脱苄反应,收率92%。将Pd/C-甲酸铵应用于催化溴那维定脱溴制得加兰他敏的重要中间体那维定,收率75%。

Using Pd/C-（ ammonium formate） as the catalyst, an important intermediate of salmeterol, 1-（ 2,2-dimethyl-4H-I, 3-benzodioxin-6-yl ） -2-（ 2-hydroxy-1 -phenylethylamino ） ethanol, was debenzylized by catalytic transfer hydrogenolysis in yield of 92%, and the important intermediate of galanthamine, narwedine, was obtained from bromonarwedine by debromination in yield of 75%.