摘要
以N-Boc-L-缬氨酸为起始原料,经四步反应(最后一步用苯丙酰氯为苯丙酰化试剂)高产率地合成了蛋白质MyD88的小分子拟似物——N-(N'-3-苯丙酰-L-缬氨酰)四氢吡咯(AS-1),其结构经1H NMR和MS确证,总收率42%,纯度高于98%。
A low molecular weight MyD88 mimic, N-(N'-3-phenylpropionyl-L-valyl)pyrrolidine( AS- 1 ), was synthesized from N-Boc-L-valine by a four-step reaction route using 3-phenylpropionyl chloride as the propylenelation agent in the final step. The structures were confirmed by I H NMR and MS. The tatol yield was 42% with purity over 98%.
出处
《合成化学》
CAS
CSCD
北大核心
2012年第3期396-398,共3页
Chinese Journal of Synthetic Chemistry
基金
国家自然科学基金资助项目(20872040
21072067)
中央高校基本科研业务资助项目(2010ZD007)