补肾调经汤对卵巢早衰患者性激素的影响

Effect of BushenTiaojing Decoction on Sex Hormone of Patients with Premature Ovarian Failure

目的:观察补肾调经汤治疗卵巢早衰(POF)的临床疗效及其对性激素的影响。方法:46例POF患者随机分为两组,治疗组23例予补肾调经汤治疗,对照组23例予激素替代治疗,疗程3个月。治疗结束后随访3个月,观察两组患者治疗前、治疗结束时、停药3个月的临床症状积分,性激素水平[卵泡刺激素(FSH)、雌二醇(E2)、黄体生成素(LH)]。结果:治疗组、对照组的总有效率分别为91.3%、69.6%(P<0.05);治疗结束时,两组患者血清E2升高(P<0.01),FSH、LH下降(均P<0.01),症状总积分下降(P<0.05或<0.01);停药3个月,对照组血清E2、FSH、LH水平和症状总积分,与治疗组比较差异有显著性(P<0.05或<0.01)。结论:补肾调经汤治疗卵巢早衰的疗较显著,能明显地改善患者的临床症状,且不良反应少,复发率低,可值在临床推广应用。

Objective： To explore the effect of Bushen Tianjing Decoction on sex hormone of patients with premature ovarian failure. Methods： 46patients with POF were randomly divided into two groups, 23cases of the treatment group took Bushen Tiao- jing Decoction, 23cases of the control group took hormone replacement therapy, all patients accepted 3months of treatment. After treatment, follow-up 3months and withdrawal 3months, the clinical symptom score, sex hormone levels （FSH, E2, LH） were observed before and the end of treatment. Results ： Total effective rate of the treatment group and the control group were 91.3%, 69. 6% （P〈0. 05）; at the end of treatment, the serum E2 levels increased （P〈0.01） and FSH, LH levels decreased （P〈 0. 01） and total symptom score decreased （P〈0. 05or P〈0.01 ） in the two groups; withdrawal 3months, the serum E2, FSH, LH levels and symptoms total score in the control group had significant difference when comparing with the treatment group （P〈0. 05or P〈0. 01 ）. Conclusion： Bushen Tiaojing Decoction has more significant effect on premature ovarian failure, and can sig-nificantly improve patient＇s clinical symptoms, adverse reactions and relapse rate. It is valuable in clinical application.