摘要
目的探讨β2肾上腺素能受体(β2-AR)基因多态性对β2肾上腺素受体激动剂治疗婴幼儿毛细支气管炎疗效的影响。方法采用PCR扩增目的基因,以DNA直接测序法对β2肾上腺素能受体基因多态性进行分析,以喘憋、咳嗽、哮鸣音、啰音消失天数和住院天数评价β2肾上腺素受体激动剂的治疗效果。结果 (1)β2-AR 16位点多态性中Gly/Gly纯合子、Gly/Arg杂合子及Arg/Arg纯合子喘憋消失天数、咳嗽消失天数、哮鸣音消失天数、啰音消失天数和住院天数差异均有统计学意义(P<0.05)。(2)β2-AR 27位点不同基因型之间,喘憋消失天数、咳嗽消失天数、哮鸣音消失天数、啰音消失天数和住院天数未见明显差异。结论β2-AR 16位点多态性与β2肾上腺素受体激动剂治疗毛细支气管炎疗效具有相关性。
Objective To explore the impact of β2-adrenergic receptor（β2-AR） genetic polymorphism on β2receptor agonist treatment of infants with bronchiolitis. Methods After amplifing the target gene of PCR and analyzing β2-AR genetic polymorphismof DNA sequen mong the bronchioliti children with different genotype of a cing, β2-A the improvement of clinical symptoms a R receptor agonist treatment were further analyzed. Results （1）β2-AR 16 loci in the last days of clinical symptoms have significant differences （P〈0.05）. （2）β2-AR 27 loci in the last days of clinical symptoms haven′t significant difference （P〈0.05）. Conclusion β2-AR 16 loci polymorphism is correlated with β2 receptor agonist treatment of bronchiolitis.
出处
《新疆医科大学学报》
CAS
2012年第5期613-616,共4页
Journal of Xinjiang Medical University
基金
国家自然科学基金项目(81060072)
