保妇康栓联合聚甲酚磺醛液治疗高危HPV感染的CINⅠ的临床研究

Efficacy of Baofukang suppository combined with policresulen solution in the treatment of CINⅠand high risk-HPV infection

目的探讨保妇康栓联合聚甲酚磺醛液治疗高危HPV感染的CINⅠ的疗效。方法我院妇科门诊就诊女性诊断CINⅠ同时合并高危HPV感染240例,随机分为4组:单纯保妇康栓治疗组、单纯聚甲酚磺醛浓缩液治疗组、保妇康栓+聚甲酚磺醛浓缩液治疗组、不使用任何药物的空白对照组,每组60例,对各组CINⅠ消退及高危HPV转阴率进行对比分析。结果治疗组的CINⅠ消退及高危HPV转阴率均高于空白对照组,保妇康栓+聚甲酚磺醛浓缩液治疗的疗效最佳(P<0.05)。两组均无严重不良反应。结论保妇康栓联合聚甲酚磺醛液的中西医结合治疗高危HPV感染的CINⅠ安全、有效。

Objective To investigate the clinical efficacy of Baofukang suppository combined with policresulen solution in the treatment of cervical intraepithelial neoplasia（CINⅠ） patients with high risk human papillomavirus（hr-HPV） infection. Methods A total of 240 women diagnosed as CINⅠcombined with hr-HPV infection were randomly divided into 4 groups：Baofukang suppository group（n=60）,policresulen solution group（n=60）,Baofukang suppository＋policresulen solution group（n=60）,and blank control group（n=60）.The response rates of CINⅠand hr-HPV infection were compared. Results The response rates in treatment groups were significantly higher than that in control group,especially in Baofukang suppository＋policresulen solution group（P0.05）.No severe side effects occurred. Conclusion Baofukang suppository combined with policresulen solution in the treatment of CINⅠand hr-HPV infection is a safe and effective method.