EBV、ERK1、Ki67在不同临床分型宫颈癌中的表达及其相关性

The expression and correlation between EBV,ERK1 and Ki67 and different clinical classification of cervical cancer

目的研究EBV、ERKl和Ki67在同临床分型宫颈癌中的表达及相互关系,以探讨宫颈癌的发病机制及其临床意义。方法选择经手术治疗、有明确病理诊断的宫颈癌患者共109例,其中Ⅰ期31例,Ⅱ期14例,Ⅲ期37例和Ⅳ期27例,使用免疫组织化学染色法检测EBV的表达、ERKl和Ki67的表达。同时选取30例正常宫颈石蜡切片作为对照组。结果 EBV、ERKl和Ki67表达随着宫颈癌临床分型而逐渐增加,与0期和Ⅰ期相比,差异均有统计学意义,P<0.05。结论 EBV感染可能是宫颈癌发生原因之一,ERKl的表达以及Ki67可作为评价宫颈癌的发生、发展中的重要指标。

Objective To search the relationship between the expression of EBV,ERK 1 and Ki67 and different clinical classification of cervical cancer and try to explore the pathogenesis of cervical cancer and its clinical significance.Methods A total of 109 cases of clear pathological diagnosis of cervical cancer patients,including stageⅠ（31 cases）,Ⅱ（14 cases）,Ⅲ（37 cases） and Ⅳ（27 cases）.Immunohistochemical staining was used to detect EBV,ERK 1 and Ki67 expression.And 30 paraffin sections of normal cervix people served as controls.Results The expression of EBV,ERK 1 and Ki67 gradually increased as cervical cancer clinical classification.The differences were statistically significant（P〈0.05） compared with stage 0 and Ⅰ.Conclusion EBV infection may be one of the causes of cervical cancer and ERK 1 and Ki67 expression may play an important indicator evaluation of occuring and development of cervical cancer.