依托咪酯与丙泊酚用于无痛宫腔镜检查的临床效果比较

COMPARISON OF CLINICAL EFFECT BETWEEN ETOMIDATE AND PROPOFOL IN ANALGESIC HYSTEROSCOPY

目的比较依托咪酯和丙泊酚用于门诊无痛宫腔镜检查的临床效果。方法选择160例门诊宫腔镜检查的患者,ASAⅠ～Ⅱ级,随机分为二组,每组80例。麻醉采用静注咪哒唑仑1mg,1min后静注芬太尼2μg/kg,随后注入。A组丙泊酚2mg/kg,B组依托咪酯0.2mg/kg,监测记录MAP、心率(HR)、脉搏血氧饱和度(SpO2),观察记录术中镇痛效果,术后恢复时间及静脉注射痛发生率。结果二组术中镇痛效果及术后恢复时间无明显差异,A组MAP、HR明显下降(P<0.05),A组静脉注射痛发生率显著高于B组(P<0.05)。结论依托咪酯和丙泊酚均可为无痛宫腔镜检查提供有效的麻醉。但依托咪酯具有血流动力学稳定、静脉注射痛发生率低的优点。

Objective To compare the clinical effect of etomidate and propofol when used for analgesic hysteroscopy. Methods One hundred and sixty clinical volunteers of patients were randomly divided into two groups, with 80 members for each. Each person received 1mg midazolam and one minute later 2μg/kg fentanyl for anaesthesia. Alter that group A received 2mg/kg propofol and group B 0. 2mg/kg etomidate. The levels of MAP,HR,SpO2 were monitored and recorded at three time points during anesthesia, meanwhile the intraoperative analgesic effect, the postoperative recovery time and the occurrence rate of intravenous injection pain were recorded for the two teams. Results There were no significant differences in terms of the intraoperative analgesic effect and the postoperative recovery time between two groups. The levels of MAP, HR and SpO2 in group A significantly declined （P〈0.05）. The occurrence rate of intravenous injection pain in group A was notably higher than that in group B （P〈0.05）. Conclusion Both the etomidate and propofol can be effective in analgesic hysteroscopy. The only difference is that the former presents strong points of stable hemodynamics and lower occurrence rate of intravenous injection pain.