血清同型半胱氨酸水平与脑卒中相关性探讨

Association between serum homocysteine and dtoke in older patients

目的探讨血清同型半胱氨酸(Hcy)水平与脑卒中的相关性。方法采用循环酶法测定187例脑卒中患者和127例健康对照者的血清Hcy水平,两样本均数比较采用t检验,多个样本之间的比较采用方差分析。结果脑卒中患者组内有无糖尿病、高血压、高血脂、吸烟史和酗酒史者Hcy水平差异无统计学意义(P>0.05),一些脑卒中危险因素的有无与Hcy水平之间有一定的相关性。脑卒中组内男性血清Hcy与女性相比,差异也有统计学意义(P<0.05)。缺血性脑卒中与失血性脑卒中之间相比,差异无统计学意义(P>0.05)。脑卒中不同类型Hcy水平之间差异无统计学意义(P>0.05),但动脉粥样硬化性血栓性脑梗死、脑腔梗死、脑栓塞和脑出血的血清Hcy水平均高于短暂性脑缺血发作和蛛网膜下腔出血组。结论高Hcy血症是脑卒中的独立危险因素,并且与部分传统危险因素有一定的相关性。

Objective To investigate the relationship between homocysteine （Hcy） and stroke in older patients. Methods Serum Hcy concentration was measured using cycling enzymatic method in 187 stoke patients and 127 healthy people. Two sampler was compared by t test,and the comparison between multiple samples was used the analysis of variance. Results The result showed that there was not statistically significant difference in serum Hcy level between patients with diabetes, hypertension, high cholesterol, smoking and alcohol history or without them （P〉0.05）. But the presence or absence of certain risk factors had some relevance with Hcy levels for stroke. The difference was statistically significant between male stroke patients and female （P〈0.05）. The difference was not statistically significant between ischemic stroke and hemorrhagic stroke（P〉0.05）. Hcy levels in different types of stroke had no statistically significant difference （P〉0.05）, but Hcy levels of ATCI, brain stem cavity,CI and cere bral hemorrhage were higher than that in TIA and SAH group. Conclusion High Hcy hyperlipidemia is an independent risk factor for stroke,and there are some correlations with the traditional risk factors.