血必净注射液对脓毒症急性肾损伤的保护作用

The protective effect of Compound Xuebijing injection of traditional Chinese drugs on septic acute injury of kidney

目的观察血必净注射液对脓毒症急性肾损伤(AKI)的保护作用。方法收集107医院ICU 2008-09～2010-06发生脓毒症AKI 56例成年患者的临床资料进行回顾性分析。其中,观察期间每天抽血检测C反应蛋白(CRP)、血肌酐(Cr)、血胱抑素C(Cys-C)等,并监测24 h尿量、患者是否需要肾替代治疗(RRT)及预后等,并根据相关公式计算肾小球滤过率(GFR)。所有患者随机分为血必净治疗组(X组)和对照组(C组),观察两组患者的肾功能指标及总体预后等。结果 X组给予血必净治疗后第3天CRP显著低于C组(P<0.05),治疗第4天开始则X组的Cys-C水平显著低于C组(P<0.05),同时由此计算出的GFR则显著高于C组(P<0.05),而Cr在第5天两组患者之间才有显著性差异(P<0.05)。两组患者中需要RRT的比例和总体病死率无显著性差别(P>0.05)。结论血必净注射液可明显改善脓毒症AKI患者的肾功能指标,对肾功能具有明显的保护作用。

Objective To observe renal protective effect of Xuebijing injection on septic acute kidney injury（AKI）.Methods Clinical data of 56 adult septic AKI patients without immunoparalysis were collected and analysed retrospectively.The patients were divided into Xuebijing therapy group（Group X） and control group（Group C） randomly.As patients admitted,blood Cystatin C（CyS-C）,Creatinine（Cr） and C 1reactive protein（CRP） were monitored,and urine volume of 24hr,renal replace therapy（RRT） requirement,mortality were recorded.Glomerular filtration rate（GFR） was estimated based on SCys-C.Results CRP level of Group X was obviously lower than Group C on the 3rd day（P〈0.05）.Although Cys-C of Group X was still increased after therapy,it was obviously lower than Group C（P〈0.05） on the 4th day,and estimated GFR of Group X was obviously higher than Group C（P〈0.05）.While Cr level of Group X was obviously higher than Group C on the 5th day.There was no significant difference in RRT requirement and mortality between two groups（P〈0.05）.Conclusion Xuebijing injection would protect kidney from sepsis.