D-二聚体单克隆抗体制备及其在免疫荧光快速定量检测中的应用
被引量:3
摘要
D-二聚体(D.dimer,D.D)是纤维蛋白单体经活化因子XIII作用后形成的交联纤维蛋白凝块,再经纤溶酶水解所产生的一种特异性降解产物,医学应用上将它作为一个特异性的纤溶过程标记物,反映纤维蛋白溶解功能。与纤维蛋白破坏有关的疾病,如深静脉血栓形成(DVT)、肺栓塞(PE)和弥漫性血管内凝血(DIC)等,均可导致体内D—D水平升高。近年来D.D的临床应用范围越来越广,除了以上提及的疾病外,在恶性肿瘤、糖尿病、肝脏疾病。
出处
《中国医药生物技术》
CSCD
2012年第3期224-228,共5页
Chinese Medicinal Biotechnology
基金
"重大新药创制"科技重大专项(2011ZX09506-001)
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