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D-二聚体单克隆抗体制备及其在免疫荧光快速定量检测中的应用 被引量：3

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摘要 D-二聚体（D．dimer，D．D）是纤维蛋白单体经活化因子XIII作用后形成的交联纤维蛋白凝块，再经纤溶酶水解所产生的一种特异性降解产物，医学应用上将它作为一个特异性的纤溶过程标记物，反映纤维蛋白溶解功能。与纤维蛋白破坏有关的疾病，如深静脉血栓形成（DVT）、肺栓塞（PE）和弥漫性血管内凝血（DIC）等，均可导致体内D—D水平升高。近年来D．D的临床应用范围越来越广，除了以上提及的疾病外，在恶性肿瘤、糖尿病、肝脏疾病。
作者 康可人 吴培钿 卢艳华 张健 唐时幸 王继华
机构地区 华南理工大学生物科学与工程学院 广州万孚生物技术有限公司国家地方联合自检型快速检测工程实验室
出处 《中国医药生物技术》 CSCD 2012年第3期224-228,共5页 Chinese Medicinal Biotechnology
基金 "重大新药创制"科技重大专项(2011ZX09506-001)
关键词 D-二聚体 临床应用 快速定量检测 免疫荧光 抗体制备 单克隆 纤维蛋白溶解功能 弥漫性血管内凝血
分类号 R446.6 [医药卫生—诊断学]
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参考文献14

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同被引文献40

  • 1杨军,王毅,黄津,罗涛,姚智.血浆纤维蛋白原、D-二聚体检测在骨创伤致深静脉血栓形成中的应用价值[J].微循环学杂志,2005,15(2):61-62. 被引量：30
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中国医药生物技术
2012年 第3期

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