D-二聚体和急性脑卒中梗塞体积的关系

CORRELATION BETWEEN SERUM D-DIMER LEVEL AND VOLUME OF ACUTE ISCHEMIC STROKE

目的探索急性脑卒中D-二聚体的水平与脑梗塞体积之间的关系和急性脑卒中D-二聚体的变化与临床疗效之间的关系。方法对挑选的59例患者分为溶栓组和阿加曲班组,入组时和治疗7 d后进行D-二聚体的动态监测,同时进行各项功能指标测定。结果入组时D-二聚体水平和梗塞体积之间呈正相关(p<0.05),7 d后无相关(p>0.05),D-二聚体和临床疗效之间无显著相关(p>0.05)。结论急性脑卒中初发时D-二聚体水平和梗塞体积之间呈正相关。因此,D-二聚体水平可以作为预测梗塞体积及治疗反应的一项有效指标。

Objective This study aimed to investigate the relationship between D - dimer level and infarc- tion volume and the relationship between D - dimer change and clinical outcome in AIS. Methods We analyzed the D - dimer levels of 59 acute ischemic stroke patients in our department both upon admission and after seven days of initial treatment. Each patient＇s National Institute of Health Stroke Scale score, modified Rankin Scales score, Glas- gow outcome score, and infarction volume were also evaluated. Results A statistically positive correlation between initial D -dimer value and stroke volume （p 〈 0. 05 ）. However, D - dimer value did not correlate statistically with stroke volume at the 7th day after stroke （p 〉 0. 05）. No correlation between the D - dimer of the groups and the clin- ical outcome groups was found（p 〉 0. 05 ）. Conclusion The D - dimer level correlates positively with acute ischemic volume. D - dimer can be considered as a valuable marker for predicting infarction volume in acute ischemic strokes and treatment response.