中药药对的系统研究(Ⅴ)--丹参三七药对研究

Systematic Study of Chinese Medicine Herb Pairs(Ⅴ)—— Herb Pair of Salvia Miltrorrhiza and Panax Notoginseng

丹参三七是常用的药对之一,两药均具有活血化瘀的功效,配伍后药效协同,具有良好的心血管、胃肠道及肝脏保护作用,临床上常用于冠心病、心绞痛及气滞血瘀所致的胸痹、心悸气短、胸闷气短等的治疗。目前已经上市的丹参三七药对剂型有复方丹参片、复方丹参颗粒、复方丹参滴丸、冠心丹参片、冠心丹参胶囊等。近年来,随着单味药丹参和三七的化学成分及药理作用研究的不断深入,对丹参三七药对的探索也逐步开展。丹参和三七不同比例的配伍应用,会影响其有效成分的溶出、吸收、代谢以及主要的药理作用。本文主要对丹参三七药对的物质基础、药理研究及应用进展进行了总结和分析,旨在为丹参三七药对的进一步研究与开发提供参考。

A famous herb pair consisting of Salvia miltrorrhiza （SM） and Panax notoginseng （PN） possesses signifi- cant protective functions on the cardiovascular, gastrointestinal and liver because their congenial effects become stronger after combination. It was widely used in the treatments of coronary heart disease, angina pectoris, and symptoms caused by Qi and blood stagnation such as palpitation and chest distress. Nowadays, there are already various preparations consist of SM and PN on the market such as Compound Danshen tablets, Compound Danshen granules, Compound Danshen drops, Coronary Danshen tablets, Coronary Danshen capsules and so on. During the past few decades, the herb pair had attracted more and more scientists~ attention for the gradual clarification. Differ- ent combination ratio is essential to the extraction, stability and pharmacologic effect of their active ingredients. This paper mainly focuses on the summary of present development on the herb pair, in order to provide more references for the further research of herb pair of SM and PN.