金黄色葡萄球菌基因调节系统研究进展

Advances in research of gene regulation systems in Staphylococcus aureus

金黄色葡萄球菌是人类的一种重要病原菌,可以引起许多临床表现不同的感染性疾病。它所致感染的多样性和严重度取决于不同毒力因子的协同表达,而这些数量众多的毒力因子的表达会受到不同调节系统的控制,同时这些调节系统之间也存在着复杂的相互作用关系。这些基因调节系统主要有两大类:一类是双组分信号转导系统(如Agr、SaeRS、SrrAB、ArlSR、LytRS、WalKR);另一类是转录因子(如Sar、Rot、MgrA、SigmaB)。它们的协同作用有助于金黄色葡萄球菌对外界环境信号做出反应,调节致病过程中毒力因子在不同情况下的表达。

Staphylococcus aureus, as an important human pathogen, can cause various infectious diseases with different clinical manifestations. The diversity and severity of these infections depend on the coordinated expression of numerous virulence factors, which are regulated by a series of gene regulation systems that may interact with each other forming a complex network. They can be divided into two major groups： two-component signal transduction systems （i.e. Agr, SaeRS, SrrAB, ArlSR, LytRS and WalKR）, and transcription factors （i.e. Sar, Rot, MgrA and SigmaB）. Through the cooperation of these gene regulation systems, bacteria can both react to environmental stresses, and regulate the expression of virulence factors in different situations of pathogenic course.