胺碘酮对难治性心律失常QT离散度的影响

Effect of amiodarone on QT dispersion in refractory arrhythmia

目的观察胺碘酮对难治性心律失常校正QT离散度(corrected QT dispersion,QTcd)的影响。方法观察58例难治性心律失常患者静脉应用胺碘酮治疗前后校正的QTcd的变化。结果难治性心律失常组QTcd显著高于对照组,差异有统计学意义86.21±28.12 vs.41.22±30.45,t=2.903,P<0.01)。难治性心律失常组应用胺碘酮治疗后QTcd与治疗前比较明显缩小,差异有统计学意义(52.58±20.28 vs.86.21±28.12,t=2.327,P<0.05)。结论胺碘酮治疗难治性心律失常能缩小QTcd,可降低严重心律失常和心源性猝死的发生,且安全可靠,值得临床广泛应用。

Objectives To observed effect of amiodarone on corrected QT dispersion（QTcd） of refractory arrhythmia.Methods QTcd before and after amiodarone treatment in 58 patients with refractory arrhythmia were measured and compared.Results QTcd in refractory arrhythmia group was significantly higher than that of control group（86.21±28.12 vs.41.22±30.45,t= 2.903,P0.01）.QTcd in refractory arrhythmia group after treatment was significantly reduced than before（52.58±20.28 vs.86.21±28.12,t=2.327,P0.05）.Conclusions Amiodarone treatment of refractory arrhythmia is a safe and reliable strategy which can reduce QTcd and decrease occurrence of severe arrhythmia and sudden cardiac death.It is worthy of applying in clinic.