复方苦参注射液联合帕米膦酸二钠治疗恶性肿瘤骨转移疼痛的效果观察

Clinical efficacy of treating pains suffered from metastatic bone cancer with composite kushen injection and pamidronate disodimn injection

目的探讨复方苦参注射液联合帕米膦酸二钠治疗恶性肿瘤骨转移疼痛的临床疗效。方法回顾性分析60例恶性肿瘤骨转移疼痛患者的临床资料，根据治疗方法不同分为对照组和治疗组，每组30例，对照组单纯应用帕米膦酸二钠治疗；治疗组在对照组基础上联合复方苦参注射液治疗。3周期后观察两组患者的骨痛缓解率、功能状态评分和不良反应。结果3周期后治疗组与对照组的骨痛客观缓解率分别为60．0％（18／30）和30．0％（9／30），差异有统计学意义（Х^2=5．455，P=0．020）；不良反应发生率分别为40．0％（12／30）和46．6％（14／30），差异无统计学意义（Х^2=0．271，P=0．602）。治疗组治疗后功能状态评分较治疗前改善[（2．30±0．70）、（1．80±0．80）分]，差异有统计学意义（t=15．000，P=0．042），对照组治疗前后功能状态评分变化不明显。结论复方苦参注射液联合帕米膦酸二钠治疗恶性肿瘤骨转移疼痛有明显协同作用，能提高近期疗效，明显改善患者疼痛症状及生活质量。

Objective To explore the clinical efficacy of treating pains suffered from metastatic bone cancer with composite kushen injection and pamidronate disodium injection. Methods The clinical information of 60 cases of metastatic bone cancer patients suffered with pains was collected retrospectively. Thirty patients were assigned to the treatment group and 30 to the control group according to the treatment they underwent. The control group were treated with pamidronate disodium injection for 3 cycle, the treatment group were additionaly treated with composite kushen injection. The differences of two groups cases were compared in respect of the relief of pains and the changes of performance status（PS）and the incidence of adverse effects after treatment for 3 cycles. Results The objective remission rate of bone pain was 60. 0% （18/30） in the treatment group,which was significantly higher than that of 30. 0% （9/30） in the control group was higher（ Х^2 = 5.455 ,P = 0. 020 ）. The incidence of adverse effect was 40. 0% （12/30） in the treatment group and 46. 6% （14/30） in the control group, with no significant difference between the two groups （X^2 = 0. 271, P = 0. 602）. In the treatment group the performance status of patients was （ 2. 30 ± 0. 70 ） after treatment, which was better than that of （ 1.80 ± 0. 80 ） before treatment （t = 15. 000,P = 0. 042）, wheras there was no significant difference on performance status in the control group. Conclusion Kushen injection has synergistic effect with pamidronate disodium injection in treating pains with matstatic bone cancer. It could improve the short term efficacy, and significantly relief the pain and improve the quality of life.