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CD26在肾癌细胞中的表达及对迁移能力的影响 被引量：1

CD26 Expression and Effect on Migration in Renal Carcinoma Cell
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摘要 目的:探讨CD26在肾癌细胞中的表达及对迁移能力的影响。方法:采用分子生物学的方法检测人肾癌细胞系A498和786-0中CD26蛋白的表达及对迁移能力的影响。结果:A498细胞内CD26蛋白表达相对水平高于786-O细胞内CD26蛋白表达,二者具有统计学意义(P<0.05);抗CD26抗体和酶抑制剂能够显著抑制细胞迁移的进程。结论:CD26蛋白表达水平可能和肾癌细胞恶性度及迁移能力相关。 Objective To study the CD26 expression in the renal carcinoma cell and its effect on the migration of renal carcinoma cell.Methods The CD26 protein expression and its effect on the migration of renal carcinoma cell line A498 and 786-O were detected by molecular biology method.Results The relative level of CD26 expression in A498 cell line was higher than that in 786-O cell line,and there was statistical significance（P0.05）.The anti-CD26 mono-antibody and the inhibitor of enzyme could significantly inhibit the cell migration process.Conclusion The expression of CD26 protein may have a relationship with the malignant and the migration ability of renal carcinoma cell.
作者 孙涛 李艳花 曹丽梅 金龙云
机构地区 牡丹江医学院红旗医院
出处 《医疗卫生装备》 CAS 2012年第5期72-73,共2页 Chinese Medical Equipment Journal
基金 黑龙江省卫生厅课题(2010-266)
关键词 CD26 分子生物学 肾癌 迁移能力 CD26 molecular biology renal cell carcinoma migration ability
分类号 R737.11 [医药卫生—肿瘤]
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参考文献11

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同被引文献18

  • 1王忠民,姜继勇,卢永科,叶萍.CD26/DPP Ⅳ基因表达对卵巢癌移植瘤生物行为的影响[J].中华临床医师杂志（电子版）,2011,5(10):2851-2855. 被引量：2
  • 2Jang J, Arni S, Perparim L,et al. The inhibition of CD26/DPP4 re- duces lung tumour growth in mice[ J]. Lung Cancer, 2013,80( S1 ) : $4 - $5.
  • 3Komiya E, Ohnuma K, Yamazaki H,et al. CD26 - mediated regula- tion of periostin expression contributes to migration and invasion of ma- lignant pleural mesothelioma ceils [ J ]. Biochemical and Biophysical Research Communications ,2014,447 (4) :609 - 615.
  • 4Eric' - Nikolid A, Matic' I Z, Dordevic' M ,et al. Serum DPPIV activity and CD26 expression on lymphocytes in patients with benign or malig- nant breast tumors [ J ] Immunobiology, 2011,216 ( 8 ) : 942 - 946.
  • 5Leicht S, Shipkova M , Klett C. CD26/dipeptidyl peptidase IV: A comparative study of healthy persons and kidney transplant recipients before and early after transplantation [ J ]. Clinical Biochemistry, 2013,46(15) :1383 - 1388.
  • 6Tan CW, Lee YH, Tan HH. CD26/DPPIV down - regulation in endo- metrial stromal cell migration in endometriosis[ J]. Fertil Steril,2014, 102(1) :167 - 177.
  • 7Aso Y, Terasawa T, Kato K ,et al. The serum level of soluble CD26/ dipeptidyl peptidase4 increases in response to acute hyperglycemia af- ter an oral glucose load in healthy subjects : association with high - mo- lecular weight adiponeetin and hepatic enzymes[J]. Translational Re- search, 2013,162 (5) :309 - 316.
  • 8Aso Y, Ozeki N, Terasawa T,et al. Serum level of soluble CD26/ dipeptidyl peptidase - 4 ( DPP - 4 ) predicts the response to sitaglip- tin, a DPP -4 inhibitor, in patients with type 2 diabetes controlled inadequately by mefformin and/or sulfonylurea[ J]. Translational Re- search 2012 ,159(1) :25 -31.
  • 9Moro PJ, Quilici J, Giorgi R. Mononuclear cell adenosine deaminase and CD26/dipeptidyl peptidase - 1V activities are sensitive markers of reperfusion during percutaneous transluminal angioplasty[ J]. Interna- tional Journal of Cardiology ,2013,166 ( 1 ) : 225 - 229.
  • 10Simone P, Broek AJ, Rensing BJ,et al. Reduced CD26 expression is associated with improved cardiac function after acute myocardial in- farction Insights from the REPERATOR Study[ J]. Journal of Molecu- lar and Cellular Cardio!ogy, 2012,53 ( 6 ) :899 - 905.

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医疗卫生装备
2012年 第5期

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