电针与益生菌合用黛力新对腹泻型肠易激综合征的疗效比较研究

Comparison of the Therapeutic Effects of Electroacupuncture and Probiotics Combined with Deanxit in Treating Diarrhea-Predominant Irritable Bowel Syndrome

目的探讨和比较电针与益生菌合用黛力新对腹泻型肠易激综合征(diarrhe atype of irritable bowel syndrome,D-IBS)的临床疗效。方法采用随机数字表法将64例伴有焦虑和(或)抑郁的D-IBS患者随机分成西药组(30例)和电针组(34例),西药组口服益生菌(地衣芽孢杆菌)和黛力新片,电针组予针刺后加电刺激,两组均治疗4周,并随访3个月。观察两组治疗前后消化道症状评分和汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评分,以及3个月的随访复发情况。结果西药组总有效率为86.67%,电针组总有效率为88.24%,两组比较,差异无统计学意义(P>0.05)。两组治疗前后消化道症状评分、HAMA和HAMD量表评分组内比较差异均有统计学意义(P<0.05,P<0.01)。两组在排便次数评分和HAMA、HAMD量表评分改善方面比较,差异无统计学意义(P>0.05);腹痛、腹胀评分改善情况电针组优于西药组(P<0.01);粪便形状和黏液便评分改善西药组优于电针组(P<0.01);随访2个月内两组复发率比较,差异无统计学意义(P>0.05),随访3个月内电针组复发率明显低于西药组(P<0.05)。结论电针与益生菌合用黛力新均能有效治疗伴有焦虑和(或)抑郁的D-IBS,且在症状改善方面各有优势,但电针远期疗效较西药更好。

Objective To study and compare the therapeutic effects of electroacupuncture and probiotics combine Deanxit in treating diarrhea predominant irritable bowel syndrome （D-IBS）. Methods Totally 64 D-IBS patients accompanied with anxiety and/or depression were randomly assigned to the Western medicine group （ Group A） and the electroacupuncture （EA） group （ Group B）, 30 patients in Group A and 34 patients in Group B. Patients in Group A took Bnfillus licheniformis and Deanxit, while those in Group B received EA. Four weeks consisted of one therapeutic course. Three-month follow-up was carried out. The scoring for the digestive tract symptoms, HAMA score, and HAMD score were evaluated before and after treatment. The recurrence in the 3- month follow-up was also observed. Results The total effect rate was 86. 67% in Group A and 88.24% in Group B with no statistical difference between the two groups （P 〉0.05）. There was statistical difference in the scoring for the digestive tract symptoms, HAMA score, and HAMD score （ P 〈0.05, P 〈0.01 ）. There was no statistical difference in the improvement of defecation frequency score, HAMA score, HAMD score between the two groups after treatment （ P 〉 0. 05）. Better effects on improving abdominal pain score and abdominal distention score was obtained in Group B （ P 〈0.01 ）, while better effects on improving the stool form score and mucus score were obtained in Group A （P〈0.01）. There was no statistical difference in the recurrence rate between the two groups within the two-month follow-up （P 〉 0. 05）. The recurrence rate within the 3-month follow-up was obviously lower in Group B than in Group A （ P 〈 0.05）. Conclusions EA and Western medicine （ probiotics combined Deanxit）could effectively treat D-IBS patients accompanied with anxiety and/or depression. Both of them had different superiorities in improving symptoms. But EA had better long-term therapeutic effects.