甲状腺动脉栓塞术治疗Graves病的远期疗效随访

Thyroid arterial embolization for Graves disease: Following up of long term effect

目的观察甲状腺动脉栓塞治疗Graves病的远期临床疗效。方法回顾性分析2003年1月—2006年12月21例接受甲状腺动脉栓塞治疗的Graves病患者的资料。对所有患者均行双侧甲状腺上动脉及一侧甲状腺下动脉栓塞术,栓塞剂为300～500μm的聚乙烯醇颗粒。分析术后6个月、1、3、5年的有效率(好转及治愈)、复发率。结果所有患者6个月内有效率达100%,1、3、5年有效率分别为95.24%(20/21)、80.95%(17/21)、66.67%(14/21),复发率分别为4.76%(1/21),19.05%(4/21),33.33%(7/21)。术后1例1年出现甲状腺功能减低。结论甲状腺动脉栓塞治疗Graves病后近中期疗效满意,远期效果有待于进一步提高。

Objective To observe long-term effect of thyroid arterial embolization for Graves disease.Methods A retrospective database of 21 hyperthyroidism patients with Graves disease who underwent thyroid arterial embolization from Jan 2003 to Dec 2006 was collected.All the patients underwent embolization of bilateral superior thyroid artery and 1 of inferior thyroid arteries with polyvinyl alcohol（PVA） particles.The diameter of PVA particles was 300—500 μm.The clinical efficiency（improved and cure rate） and recurrent rates of 0.5,1,3,5-year after embolization were analyzed.Results All patients got 100% clinical efficiency during half-year.The clinical efficiency rate of 1,3,5-year after embolization was 95.24%（20/21）,80.95%（17/21） and 66.67%（14/21）,respectively,and recurrent rate was 4.76%（1/21）,19.05%（4/21） and 33.33%（17/21）,respectively.Hypothyroidism was observed in 1 patient 1 year after embolization.Conclusion Thyroid arterial embolization for Graves disease has good short-and mid-term results,while the long-term effect needs to be further improved.