男性下生殖道不同生物群解脲脲原体感染的构成比及与尿道炎的相关性研究

Investigation of the Relationship between Biovars of Ureaplasma Urealyticum Isolated in Lower Genital Tract and Clinical Symptoms in the Male Patients

目的:初步探讨男性下生殖道解脲脲原体不同生物群感染情况及其与尿道炎表现的相关性。方法:收集性病门诊就诊解脲脲原体(Uu)阳性的男性患者的临床菌株,并详细记录患者有无尿道炎的临床症状,以多条带抗原(MB-Ag)基因为靶位,设计分群引物,进行临床菌株的血清分群检测。结果:38株Uu中,parvo生物群占36.84%(14/38),T960生物群占63.16%(24/38),未同时检测到两个生物群。无论有无尿道炎表现的男性患者中,T960生物群的检出率均高于parvo生物群,但差异均无统计学意义(P>0.05)。结论:男性尿道的Uu感染中T960生物群检出率高于parvo生物群,但两者差异无统计学意义,其原因可能与地区分布、研究对象的差异及样本量等因素有关,有待于增大样本量进一步研究。

Objective：To investigate the relationship between biovars of Ureaplasma urealyticum（Uu） isolated in lower genital tract and clinical symptom in the male patients.Methods：A total of 38 male patients with Uu infection attending the STD clinic were enrolled in the study and isolateded Uu strains were biotyped by polymerase chain reaction（PCR） according to the multiple-banded antigen（MB-Ag） gene.Results：36.84%（14/38） of the 38 strains belonged to parvo biovar and 63.16%（24/38） belonged to T960 biovar,and no cases showed both biovars.The proportion of T960 was higher than that of parvo in patients with/without urethritis performance,but there was no statistically significant difference（P〉0.05）.Conclusion：There was no significant difference between biovars of Uu isolated in lower genital tract in the male patients in this study.We assumed that the results were affected by factors such as geographic distribution of Uu,variation of study subjects,small sample size and so on.A further study with larger sample size may help to explore the correlation between different biovars and urethretis in male.