栀子苷治疗阿尔采末病及神经保护的分子机制研究进展

Research advances of the molecular mechanism of geniposide on therapy of Alzheimer's disease and effects in neuroprotection

阿尔采末病(AD)是一种中枢神经退行性疾病,以学习记忆和认知功能障碍为主要表现。Aβ毒性级联损伤是其核心病理之一。栀子苷是栀子的主要有效成分,其苷元为京尼平。实验研究表明,栀子苷和京尼平具有抗Aβ毒性损伤、抗氧化应激,抗内质网应激、抗炎症反应及促进神经生长作用。从分子作用机制角度综述近年来栀子苷及京尼平治疗AD和神经保护作用的有关文献,以期为栀子治疗AD提供借鉴。

Alzheimer＇s disease is a progressive neurodegenerative disease characterized by memory impairment and cognitive dysfunction.Accumulating evidence points to the crucial role of β-amyloid peptide as a trigger of the pathological cascade of AD.Geniposide is the main bioactive constitute of traditional Chinese medicine Gardenia jasminoides Ellis,and its aglycon is genipin.Geniposide and genipin can significantly improve the ability of learning and memory in animals with Alzheimer＇s disease,and exerts a combination of neuroprotective function.This review focuses on the molecular mechanisms of geniposide and genipin affecting Alzheimer＇s disease and contribute to a better exploitation.