无功能性甲状旁腺囊肿临床分析

Clinical analysis on nonfunctioning parathyroid cysts： a report of six cases

目的总结无功能性甲状旁腺囊肿患者的临床病理学特点，探讨其诊断和治疗方法。方法回顾性分析北京同仁医院耳鼻咽喉头颈外科2002-2009年收治的6例甲状旁腺囊肿患者的临床资料，患者均为体检时无意中发现颈部肿物，血钙、血磷及血甲状旁腺素正常，其中5例患者影像学检查提示甲状腺下极后方有囊性肿物。结果6例患者均行手术治疗，术后病理证实为甲状旁腺囊肿，免疫组化染色甲状旁腺素、嗜铬素A及突触素均阳性。随访2～9年无复发。结论手术是治疗甲状旁腺囊肿的有效方法，最终确诊需要依赖病理学检查。

Objective To study the clinical and pathological characteristics, diagnoses and treatments of nonfunctioning parathyroid cysts. Methods Six cases of nonfunctioning parathyroid cysts treated in Tongren Hospital during 2002-2009 were retrospectively analyzed. Nonfunctioning parathyroid cysts in the six patients were inadvertently found as neck masses by physical examination. The levels of serum calcium, phosphorus and parathyroid hormone were normal. Five cases of 6 patients with imaging suggested the existence of cystic mass in the back of inferior thyroid in 5 cases of the 6 patients. Results Tumors in the 6 patients were removed surgically and diagnosed as parathyroid cysts with post-operative pathological examination. PTH （ parathyroid hormone ）, CgA （ chromogranin A ）, Syn （ synaptophysin ） expressions in the tumors were positive. No recurrence was found with follow-up of 2--9 years after operation. Conclusions Surgical resection is most effective for the treatments of nonfunetioning parathyroid cysts and pathologic examination is required for the determined diagnosis of this disease. Fine needle aspiration can be helpful for the diagnosis before operation.