砷与眼科疾病关系的研究现状

Current research of the relationship between arsenic and eye disease

传统的认识认为砷是一种剧毒物质，尤其是As2O3，不仅能导致眼表的损害，还可影响视网膜的功能。随着研究的深入，目前认为砷是一把双刃剑，其对眼部疾病亦可发挥治疗作用，如砷类制剂对视网膜病变、后发性白内障、角膜病变、黑色素瘤、滤过泡瘢痕化等的治疗效果较好。总的来说，砷对眼部的损伤作用以及对眼病治疗作用的机制研究均较少，多数研究仍处于实验阶段，但这些研究为一些眼科疾病的临床治疗提供了新的研究方向，砷与眼部疾病的实验与临床研究结果正在引起更多的关注。就砷对眼部疾病的损伤和治疗作用进行综述。

Traditionally, arsenic is thought to be a strong toxicant, especially arsenic trioxide （As2O3 ）. As2O3 leads to the damage of ocular surface, such as cornea, eonjunetiva etc. , and the evidence of its damage to retinal function also has been found. However, arsenic is a double-edged sword, because it possesses well- remedial effect on some eye diseases, including proliferative diabetic retinopathy, lens posterior capsular opaeification, keratopathy,melanoma and bleb scarring. At present, there is still few research literature was seen about the active mechanism of arsenic agents on eye damage or therapeutic effect. Some relative studies are still in an experimental stage. This offers us the new research direction in clinical treatment of eye diseases. It is believed that arsenic will play an incalculable role on experiment and clinical treatment of eye diseases as further development and research of technology. The relationship between arsenic and eye disease is summed by consulting internal and external literature.