非ST段抬高急性冠脉综合征冠脉支架植入治疗前后血液T细胞亚群的水平变化

Variation in blood T cell subgroups in patients who had non-ST segment elevation-acute coronary syndrome treated with coronary stenting

目的:了解非ST抬高型急性冠脉综合征(non-ST segment elevation-acute coronary syndrome,NSTE-ACS)冠脉支架植入治疗前后血液T细胞亚群CD3、CD4、CD8的水平变化。方法:选择2007年3月至2010年9月本院本科室的NSTE-ACS患者66例和健康对照60例用SAP法分别对66例NSTE-ACS患者冠脉支架植入治疗前后外周血T淋巴细胞亚群水平进行测定。结果:NSTE-ACS患者冠脉支架植入前及植入后第7天CD3^+、CD4^+、CD4^+/CD8^+均低于对照组,CD8^+则均高于对照组,而植入后第7天CD3^+、CD4^+、CD4^+/CD8^+高于植入前,CD8^+则低于植入前(P<0.01)。结论:NSTE-ACS患者出现的细胞免疫功能改变可能参与了NSTE-ACS的发病过程。T淋巴细胞亚群的测定可作为NSTE-ACS一个预警信号,可对冠脉支架植入治疗后病情转归进行评估。

Objective：To determine the variation in T lymphocyte subgroups （CD3, CD4 and CD8 ） in patients who had non-ST segment elevation-acute coronary syndrome （NSTE-ACS） treated with coronary stenting. Methods： We recruited 66 patients with NSTE-ACS and 60 healthy controls between March 2007 and September 2010 from the department of cardiology in our hospital. Variation in the T lymphocyte subgroups of 66 patients with NSTE-ACS before and after coronary stenting was determined using SAP method. Results： Patients with NSTE-ACS presented lower CD3 ＋ , CD4 ＋ and CD4 ＋/CD8 ＋ with the exception of elevated CD8 ＋ level at day 7 as compared with that of control group. In addition, an increase in CD3 ＋ , CD4 ＋ , CD4 ＋/CD8 ＋ and decrease CD8＋ was noted in patients with NSTE-ACS presented （all P 〈 0.01 ）. Conclusion： Variation in cellular immunity might have participated in the pathogenesis of NSTE-ACS. Detection of T lymphocyte subgroups may be indicative of NSTE-ACS due to the capacity of assessment of the prognosis in those treated with coronary stenting.