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骨髓间质干细胞对炎症性肠病肠上皮重建的作用机制 被引量：4

Mechanisms of Bone Marrow-derived Mesenchymal Stem Cells on Regeneration of Intestinal Epithelium in Inflammatory Bowel Disease
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摘要 骨髓间质干细胞(MSCs)移植是治疗炎症性肠病(IBD)的一种新方法,其可通过促进肠上皮重建修复受损组织,但其作用机制仍未完全明确。相关机制的研究主要集中在MSCs的多向分化、分泌细胞因子、调节肠道干细胞微环境三个方面。本文就相关研究进展作一综述。 Bone marrow-derived mesenchymal stem cells （MSCs） transplantation is a new approach for the treatment of inflammatory bowel disease （IBD）, which enhances recovery from colitis by promoting regeneration of intestinal epithelium. However, its mechanism is still unclear. Studies mainly focused on three aspects： multilineage differentiation potential of MSCs, cytokines secretion, and modulation of microenvironment of intestinal stem cells. This article reviewed the recent progress in studies on related fields.
作者 吴新环 钟英强
机构地区 中山大学孙逸仙纪念医院消化内科
出处 《胃肠病学》 2012年第4期245-247,共3页 Chinese Journal of Gastroenterology
关键词 骨髓 间质干细胞 炎症性肠病 上皮 重建 Bone Marrow Mesenchymal Stem Cells Inflammatory Bowel Disease Epithelium Reconstruction
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献29

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同被引文献47

  • 1ênio José Bassi,Carlos Alberto Mayora Aita,Niels Olsen Saraiva Camara.Immune regulatory properties of multipotent mesenchymal stromal cells:Where do we stand?[J].World Journal of Stem Cells,2011,3(1):1-8. 被引量：27
  • 2段进粮,聂玉强,李瑜元,杜艳蕾,沙卫红,何慧华,董伟华.大鼠骨髓间充质干细胞移植后在溃疡性结肠炎模型肠道的定位[J].广州医学院学报,2006,34(1):1-4. 被引量：27
  • 3钟小明,钟梅,余鸿.骨髓基质细胞移植治疗缺血性脑病的现状及进展[J].中国组织工程研究与临床康复,2007,11(28):5584-5588. 被引量：1
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  • 6Wong CY, Cheong SK, Mok PL, et al. Differentiation of human mesenchymal stem cells into mesangial cells in post-glomerular injury murine model [ J ]. Pathology, 2008, 40 (1) : 52-57.
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  • 9Reich K, Segaert S, Van de Kerkhof P, et al. Once- weekly administration of etanercept 50 mg improves pa- tient-reported outcomes in patients with moderate-to-severe plaque psoriasis [ J ]. Dermatology, 2009, 219 (3) : 239- 249.
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引证文献4

二级引证文献12

胃肠病学
2012年 第4期

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