核基质结合区结合蛋白质1研究进展

Advances in Study on Scaffold/matrix Attachment Region Binding Protein 1

核基质相关蛋白改变是恶性肿瘤细胞的主要表现形式,可使染色质发生折叠、基因复制保真度和基因表达发生改变。核基质结合区(MAR)结合蛋白(MARBPs)表达异常可影响染色质构成、干扰转录调控程序,致肿瘤形成。某些MARBPs特异性表达于肿瘤组织,是肿瘤诊断和预后的指标。核基质结合区结合蛋白质1(SMAR1)在乳腺癌中的表达急剧下调。本文就SMAR1在细胞生长、凋亡和肿瘤形成中的作用作一综述。

Change of nuclear matrix associated protein is one of the major phenotypes of malignant tumor cells leading to alteration in chromatin folding, the change of fidelity of genome replication and gene expression. Aberrant expression of matrix attachment region （MAR） binding proteins （MARBPs） modulates the ehromatin constitution and disruption of transcriptional network that leads to oncogenesis. Some of these proteins are expressed specifically in tumor tissue and could be served as promising diagnostic or prognostic markers. Scaffold/matrix attachment region binding protein 1 （SMAR1） expression is drastically down-regulated in breast cancer. This article reviewed the roles of SMAR1 in cell growth, apoptosis and tumorigenesis.