摘要
目的 探讨血清白介素-18和尿液白介素-8与胎膜早破并发羊膜腔感染之间的关系,从而为早期诊断羊膜腔感染综合征提供依据。方法 选择在2010年2月～2012年2月收住院分娩的胎膜早破孕妇115例和正常分娩的孕妇55例,前瞻性的进行母血清中的白细胞介素-18(IL-18)和尿中白细胞介素-8(IL-8)的检测,分娩时取胎盘胎膜组织送病检做最后诊断,将实验组分为绒毛膜羊膜炎组(实验Ⅰ组)和非绒毛膜羊膜炎组(实验Ⅱ组)。结果 (1)实验组患者尿IL-8水平均高于对照组,实验Ⅰ组尿IL-8水平明显高于实验Ⅱ组,差异均具有统计学意义(P<0.05)(;2)实验Ⅰ组和实验Ⅱ组患者在血IL-18和尿IL-8的水平上差异无统计学意义(P>0.05);(3)母血清中白介素-18(IL-18)和尿白介素-8(IL-8)的联合检测,可以明显提高检测的阳性预测值。结论 血清白介素-18和尿液白介素-8与胎膜早破并发羊膜腔感染之间密切相关,联合检测可以提高诊断的阳性预测值。
Objective To research the significance of IL-18 and IL-8 expressed in premature rupture of membranes complicated by intra-amniotic infection syndrome. Methods Treated 115 cases patients with premature rupture of membranes and 55 cases of normal childbirth pregnant woman accepted in our hospital as the object of study, prospectively detected maternal serum interleukin - 18（IL-18） and urinary interleukin 8（/L-8）, took the placenta tissue and send ill check to do a final diagnosis, The experimental group was divided into chorioamnionitis group （ experimental group ） and non chorioamnionitis group （experimental group ）. Results （1）The experimental group patients with urinary IL-8 were higher than those in the control group, the experimental group urinary IL-8 level was significantly higher in the experimental group, with statistically significant differences （P〈0.05）; （2） the experimental group and the experimental group patients in blood IL-18and urinary IL-81evel had no significant difference （P〉O.05）; （3）the mother in the serum interlettkin 18（IL-18） and urinary interleukin 8（IL-8） joint detection, can significantly improve the detection ofpositive predictive value,Conclusion Serum interleukin 18and urine interleuldn - 8 has closely related with premature rupture of membranes with infection of amniotic cavity, joint detection can improve the diagnostic positive predictive value.
出处
《当代医学》
2012年第15期1-3,共3页
Contemporary Medicine
