氟西汀治疗脑卒中后抑郁症临床分析

Clinical analysis of Fluoxetine hydrochloride in the treatment of post-stroke depression

目的观察氟西汀治疗脑卒中后抑郁症的临床疗效。方法将120例脑卒中后抑郁状态患者,依照就诊顺序随机分为观察组(加用盐酸氟西汀)和对照组(常规治疗)各60例进行对照观察。应用汉密尔顿抑郁量表(HAMD)、神经功能缺损评分(NIHSS)及Barthel指数评定疗效和不良反应。结果治疗8周后,两组患者HAMD评分、NIHSS评分较治疗前均明显降低(P<0.05或P<0.01),观察组降低幅度显著高于对照组(P<0.01)。观察组Barthel指数明显提高,与对照组比较差异有统计学意义(P<0.01)。结论氟西汀治疗脑卒中后抑郁症疗效确切,不良反应小,且可有效促进脑卒中后神经功能的恢复。

Objective To observe the clinic efficacy of Fluoxetine on post-stroke depression. Methods One hundred and twenty cases of post-stroke depression patients were randomly divided into the observation group （add with hydrochloric acid prozac） and the control group （conventional treatment） according to the doctor order, each group of 60 cases, the patients in the observation group were administered with Fuoxetine besides conventional way, the control group were treated with conventional way. Then, Hamilton Depression Scale （HAMD）, National Institute of Health stroke scale （NIHSS） and Barthel Index （BI） were used to evaluate the curative effect and adverse effects between the two groups. Results After treatment of 8 weeks, Hamilton Depression Rating Scale （HAMD） and Neural Function Defect score （NIHSS） of two groups were significantly decreased （P 〈 0.05 or P 〈 0.01）,and the range of decrease in obsevation group was more significant than control group （P 〈 0.01）. And there was a marked elevation of Barthel score in the obsevation group compared with the control group （P 〈 0.01）. Conclusion Fluoxetine is effective in treatment of post-stroke depression and is prominent on the process of neurofunctional rehabilitation with a little adverse effects.